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160 results

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Page 1
TRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells.
Zhang B, Liu B, Roos CM, Thompson MA, Prakash YS, Miller JD, Guo RW. Zhang B, et al. Channels (Austin). 2018 Jan 1;12(1):119-125. doi: 10.1080/19336950.2018.1451696. Channels (Austin). 2018. PMID: 29560783 Free PMC article.
TRPC1 knockdown significantly suppressed store-operated, channel-mediated Ca(2+) entry, but TRPC4 knockdown and TRPC6 knockdown had no effect. Separate knockdown of TRPC1, TRPC4, or TRPC6 did not have a significant effect on thapsigargin-initiat …
TRPC1 knockdown significantly suppressed store-operated, channel-mediated Ca(2+) entry, but TRPC4 knockdown and TRPC6 k …
TRPC channels: Structure, function, regulation and recent advances in small molecular probes.
Wang H, Cheng X, Tian J, Xiao Y, Tian T, Xu F, Hong X, Zhu MX. Wang H, et al. Pharmacol Ther. 2020 May;209:107497. doi: 10.1016/j.pharmthera.2020.107497. Epub 2020 Jan 28. Pharmacol Ther. 2020. PMID: 32004513 Free PMC article. Review.
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-operated calcium-permeable nonselective cation channels of the TRP superfamily. The seven mammalian TRPC members, which can be further divided into four subgroups (TRPC1, TRPC2, TRPC4 …
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-operated calcium-permeable nonselective cation …
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.
Tsvilovskyy VV, Zholos AV, Aberle T, Philipp SE, Dietrich A, Zhu MX, Birnbaumer L, Freichel M, Flockerzi V. Tsvilovskyy VV, et al. Gastroenterology. 2009 Oct;137(4):1415-24. doi: 10.1053/j.gastro.2009.06.046. Epub 2009 Jun 21. Gastroenterology. 2009. PMID: 19549525 Free PMC article.
RESULTS: In intestinal smooth muscle cells TRPC4 forms a 55 pS cation channel and underlies more than 80% of the muscarinic receptor-induced cation current (mI(CAT)). The residual mI(CAT) depends on the expression of TRPC6, indicating that TR …
RESULTS: In intestinal smooth muscle cells TRPC4 forms a 55 pS cation channel and underlies more than 80% of the muscar …
TRPC4 and TRPC4-deficient mice.
Freichel M, Philipp S, Cavalié A, Flockerzi V. Freichel M, et al. Novartis Found Symp. 2004;258:189-99; discussion 199-203, 263-6. Novartis Found Symp. 2004. PMID: 15104183 Review.
In mouse endothelial cells at least seven TRPs are expressed, including TRPC1, TRPC2, TRPC3, TRPC4, TRPC6, TRPV4 and TRPM4. As shown previously, TRPC4 is an indispensable component of agonist-induced Ca2+ entry channels in native endothelial cells which essen …
In mouse endothelial cells at least seven TRPs are expressed, including TRPC1, TRPC2, TRPC3, TRPC4, TRPC6, TRPV4 and TRPM4. As …
TRPs in olfaction.
Zufall F. Zufall F. Handb Exp Pharmacol. 2014;223:917-33. doi: 10.1007/978-3-319-05161-1_8. Handb Exp Pharmacol. 2014. PMID: 24961974 Review.
The mammalian olfactory system has become an excellent model system to understand the function of transient receptor potential (TRP) channels within their native cellular and circuit environment. The discovery that the canonical TRP channel TRPC2 is highly expressed in sen …
The mammalian olfactory system has become an excellent model system to understand the function of transient receptor potential (TRP) channel …
Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.
Zeng W, Ji Y, Zhang H, Chen L, Du L, Guo R. Zeng W, et al. Genet Res (Camb). 2021 Nov 27;2021:2949986. doi: 10.1155/2021/2949986. eCollection 2021. Genet Res (Camb). 2021. PMID: 34899056 Free PMC article.
Calcium backfilling assays were performed to detect intracellular calcium ion concentration in cultured VSMCs and VECs. RESULTS: The TRPC6 expression was more abundant in VECs than VSMCs, while TRPC4 and TRPC5 expressions were more abundant in VSMCs than VECs. Knock …
Calcium backfilling assays were performed to detect intracellular calcium ion concentration in cultured VSMCs and VECs. RESULTS: The TRPC …
C(60) fullerenes disrupt cellular signalling leading to TRPC4 and TRPC6 channels opening by the activation of muscarinic receptors and G-proteins in small intestinal smooth muscles.
Dryn DO, Melnyk MI, Al Kury LT, Prylutskyy YI, Ritter U, Zholos AV. Dryn DO, et al. Cell Signal. 2018 Mar;43:40-46. doi: 10.1016/j.cellsig.2017.12.003. Epub 2017 Dec 11. Cell Signal. 2018. PMID: 29242169
The effect of water-soluble pristine C(60) fullerene nanoparticles (C(60)NPs) on receptor-operated cation channels formed by TRPC4/C6 proteins in ileal smooth muscle cells was investigated for the first time. ...The inhibition developed rather slowly, with the time …
The effect of water-soluble pristine C(60) fullerene nanoparticles (C(60)NPs) on receptor-operated cation channels formed by TRPC4 …
Piperlonguminine attenuates renal fibrosis by inhibiting TRPC6.
Zhou L, Wu K, Gao Y, Qiao R, Tang N, Dong D, Li XQ, Nong Q, Luo DQ, Xiao Q, Fan X, Duan Q, Cao W. Zhou L, et al. J Ethnopharmacol. 2023 Sep 15;313:116561. doi: 10.1016/j.jep.2023.116561. Epub 2023 Apr 29. J Ethnopharmacol. 2023. PMID: 37121453
A total of 10 active components were obtained by molecular docking with TRPC6 protein. Among them, 4 components had an affinity with TRPC6. Piperlonguminine (PLG) had the most potent affinity with TRPC6 and blocking effect on TRPC6-mediated Ca(2+) entr …
A total of 10 active components were obtained by molecular docking with TRPC6 protein. Among them, 4 components had an affinity with …
The structure of TRPC ion channels.
Li J, Zhang X, Song X, Liu R, Zhang J, Li Z. Li J, et al. Cell Calcium. 2019 Jun;80:25-28. doi: 10.1016/j.ceca.2019.03.005. Epub 2019 Mar 14. Cell Calcium. 2019. PMID: 30928685 Review.
Briefly review the recent structural work of transient receptor potential canonical (TRPC) ion channels by using electron cryo-microscopy (cryo-EM). The high resolution structures of TRPC3, TRPC4, TRPC5 and TRPC6 are discussed....
Briefly review the recent structural work of transient receptor potential canonical (TRPC) ion channels by using electron cryo-microscopy (c …
Novel Chemical Inhibitor of TRPC4 Channels.
Miller MR, Shi J, Wu M, Engers J, Hopkins CR, Lindsley CW, Salovich JM, Zhu Y, Tian JB, Zhu MX, McManus OB, Li M. Miller MR, et al. 2010 Dec 15 [updated 2011 May 26]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2010 Dec 15 [updated 2011 May 26]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 22049577 Free Books & Documents. Review.
ML204 was identified as a novel TRPC4 channel inhibitor following a high throughput fluorescent screen of the MLSMR library and SAR analysis of active compounds. ML204 inhibited calcium influx through TRPC4 channels activated by mu-opioid receptor stimulation …
ML204 was identified as a novel TRPC4 channel inhibitor following a high throughput fluorescent screen of the MLSMR library an …
160 results